A potent liver-mediated mechanism for loss of muscle mass during androgen deprivation therapy

CONTEXT: Androgen deprivation therapy (ADT) in prostate cancer results in muscular atrophy, due to loss of the anabolic actions of testosterone. Recently, we discovered that testosterone acts on the hepatic urea cycle to reduce amino acid nitrogen elimination. We now hypothesize that ADT enhances pr...

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Bibliographic Details
Published in:Endocr Connect
Main Authors: Lam, Teresa, McLean, Mark, Hayden, Amy, Poljak, Anne, Cheema, Birinder, Gurney, Howard, Stone, Glenn, Bahl, Neha, Reddy, Navneeta, Shahidipour, Haleh, Birzniece, Vita
Format: Artigo
Language:Inglês
Published: Bioscientifica Ltd 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510709/
https://ncbi.nlm.nih.gov/pubmed/30991356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EC-19-0179
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