A potent liver-mediated mechanism for loss of muscle mass during androgen deprivation therapy

CONTEXT: Androgen deprivation therapy (ADT) in prostate cancer results in muscular atrophy, due to loss of the anabolic actions of testosterone. Recently, we discovered that testosterone acts on the hepatic urea cycle to reduce amino acid nitrogen elimination. We now hypothesize that ADT enhances pr...

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Detalhes bibliográficos
Publicado no:Endocr Connect
Main Authors: Lam, Teresa, McLean, Mark, Hayden, Amy, Poljak, Anne, Cheema, Birinder, Gurney, Howard, Stone, Glenn, Bahl, Neha, Reddy, Navneeta, Shahidipour, Haleh, Birzniece, Vita
Formato: Artigo
Idioma:Inglês
Publicado em: Bioscientifica Ltd 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510709/
https://ncbi.nlm.nih.gov/pubmed/30991356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EC-19-0179
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