Efficient reduction of synthetic mRNA induced immune activation by simultaneous delivery of B18R encoding mRNA

The application of synthetic modified messenger RNA (mRNA) is a promising approach for the treatment of a variety of diseases and vaccination. In the past few years, different modifications of synthetic mRNA were applied to render the mRNA more stable and less immunogenic. However, the repeated appl...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Eng
Hauptverfasser: Michel, Tatjana, Golombek, Sonia, Steinle, Heidrun, Hann, Ludmilla, Velic, Ana, Macek, Boris, Krajewski, Stefanie, Schlensak, Christian, Wendel, Hans Peter, Avci-Adali, Meltem
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509845/
https://ncbi.nlm.nih.gov/pubmed/31168319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13036-019-0172-5
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