Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin

In recent years, synthetic mRNA-based applications to produce desired exogenous proteins in cells have been gaining importance. However, systemic delivery of synthetic mRNA can result in unspecific uptake into undesired cells or organs and, thereby, fail to target desired cells. Thus, local and targ...

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Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Golombek, Sonia, Pilz, Martin, Steinle, Heidrun, Kochba, Efrat, Levin, Yotam, Lunter, Dominique, Schlensak, Christian, Wendel, Hans Peter, Avci-Adali, Meltem
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992458/
https://ncbi.nlm.nih.gov/pubmed/29858073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.03.005
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