Identification of PGN_1123 as the Gene Encoding Lipid A Deacylase, an Enzyme Required for Toll-Like Receptor 4 Evasion, in Porphyromonas gingivalis

Removal of one acyl chain from bacterial lipid A by deacylase activity is a mechanism used by many pathogenic bacteria to evade the host's Toll-like receptor 4 (TLR4)-mediated innate immune response. In Porphyromonas gingivalis, a periodontal pathogen, lipid A deacylase activity converts a majo...

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Bibliographic Details
Published in:J Bacteriol
Main Authors: Jain, Sumita, Chang, Ana M., Singh, Manjot, McLean, Jeffrey S., Coats, Stephen R., Kramer, Roger W., Darveau, Richard P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509663/
https://ncbi.nlm.nih.gov/pubmed/30782639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00683-18
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