The Distinct Immune-Stimulatory Capacities of Porphyromonas gingivalis Strains 381 and ATCC 33277 Are Determined by the fimB Allele and Gingipain Activity

The Porphyromonas gingivalis strain ATCC 33277 (33277) and 381 genomes are nearly identical. However, strain 33277 displays a significantly diminished capacity to stimulate host cell Toll-like receptor 2 (TLR2)-dependent signaling and interleukin-1β (IL-1β) production relative to 381, suggesting tha...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Coats, Stephen R., Kantrong, Nutthapong, To, Thao T., Jain, Sumita, Genco, Caroline A., McLean, Jeffrey S., Darveau, Richard P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867864/
https://ncbi.nlm.nih.gov/pubmed/31570556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00319-19
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