The Distinct Immune-Stimulatory Capacities of Porphyromonas gingivalis Strains 381 and ATCC 33277 Are Determined by the fimB Allele and Gingipain Activity

The Porphyromonas gingivalis strain ATCC 33277 (33277) and 381 genomes are nearly identical. However, strain 33277 displays a significantly diminished capacity to stimulate host cell Toll-like receptor 2 (TLR2)-dependent signaling and interleukin-1β (IL-1β) production relative to 381, suggesting tha...

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Vydáno v:Infect Immun
Hlavní autoři: Coats, Stephen R., Kantrong, Nutthapong, To, Thao T., Jain, Sumita, Genco, Caroline A., McLean, Jeffrey S., Darveau, Richard P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867864/
https://ncbi.nlm.nih.gov/pubmed/31570556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00319-19
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