The Distinct Immune-Stimulatory Capacities of Porphyromonas gingivalis Strains 381 and ATCC 33277 Are Determined by the fimB Allele and Gingipain Activity

The Porphyromonas gingivalis strain ATCC 33277 (33277) and 381 genomes are nearly identical. However, strain 33277 displays a significantly diminished capacity to stimulate host cell Toll-like receptor 2 (TLR2)-dependent signaling and interleukin-1β (IL-1β) production relative to 381, suggesting tha...

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發表在:Infect Immun
Main Authors: Coats, Stephen R., Kantrong, Nutthapong, To, Thao T., Jain, Sumita, Genco, Caroline A., McLean, Jeffrey S., Darveau, Richard P.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2019
主題:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867864/
https://ncbi.nlm.nih.gov/pubmed/31570556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00319-19
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