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Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior

Many proteins, such as RNA-binding proteins, have complex folding landscapes. How cells maintain the solubility and folding state of such proteins, particularly under stress conditions, is largely unknown. Here, we argue that prion-like low-complexity regions (LCRs) are key regulators of protein sol...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Franzmann, Titus M., Alberti, Simon
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509491/
https://ncbi.nlm.nih.gov/pubmed/29921587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.TM118.001190
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