SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer

Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating do...

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Опубликовано в: :Nat Commun
Главные авторы: Perone, Ylenia, Farrugia, Aaron J., Rodríguez-Meira, Alba, Győrffy, Balázs, Ion, Charlotte, Uggetti, Andrea, Chronopoulos, Antonios, Marrazzo, Pasquale, Faronato, Monica, Shousha, Sami, Davies, Claire, Steel, Jennifer H., Patel, Naina, del Rio Hernandez, Armando, Coombes, Charles, Pruneri, Giancarlo, Lim, Adrian, Calvo, Fernando, Magnani, Luca
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509342/
https://ncbi.nlm.nih.gov/pubmed/31073170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09676-y
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