MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis

In mitosis, cells inactivate DNA double-strand break (DSB) repair pathways to preserve genome stability. However, some early signaling events still occur, such as recruitment of the scaffold protein MDC1 to phosphorylated histone H2AX at DSBs. Yet, it remains unclear whether these events are importa...

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Udgivet i:Mol Cell
Main Authors: Leimbacher, Pia-Amata, Jones, Samuel E., Shorrocks, Ann-Marie K., de Marco Zompit, Mara, Day, Matthew, Blaauwendraad, Jordy, Bundschuh, Diana, Bonham, Sarah, Fischer, Roman, Fink, Daniel, Kessler, Benedikt M., Oliver, Antony W., Pearl, Laurence H., Blackford, Andrew N., Stucki, Manuel
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509287/
https://ncbi.nlm.nih.gov/pubmed/30898438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.014
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