Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility

T cell receptor (TCR) recognition of antigenic peptides bound and presented by class I major histocompatibility complex (MHC) proteins underlies the cytotoxic immune response to diseased cells. Crystallographic structures of TCR-peptide/MHC complexes have demonstrated how TCRs simultaneously interac...

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Publicat a:Front Immunol
Autors principals: Ayres, Cory M., Abualrous, Esam T., Bailey, Alistair, Abraham, Christian, Hellman, Lance M., Corcelli, Steven A., Noé, Frank, Elliott, Tim, Baker, Brian M.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509175/
https://ncbi.nlm.nih.gov/pubmed/31130956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00966
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