Pain-Induced Negative Affect Is Mediated Via Recruitment Of The Nucleus Accumbens Kappa Opioid System

Negative affective states impact quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose, and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing the...

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Udgivet i:Neuron
Main Authors: Massaly, Nicolas, Copits, Bryan A., Wilson-Poe, Adrianne R., Hipólito, Lucia, Markovic, Tamara, Yoon, Hye Jean, Liu, Shiwei, Walicki, Marie C., Bhatti, Dionnet L., Sirohi, Sunil, Klaas, Amanda, Walker, Brendan M., Neve, Rachael, Cahill, Catherine M., Shoghi, Kooresh I., Gereau, Robert W., McCall, Jordan G., Al-Hasani, Ream, Bruchas, Michael R., Morón, Jose A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509001/
https://ncbi.nlm.nih.gov/pubmed/30878290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.02.029
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