Pain-Induced Negative Affect Is Mediated Via Recruitment Of The Nucleus Accumbens Kappa Opioid System

Negative affective states impact quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose, and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing the...

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Publicado no:Neuron
Main Authors: Massaly, Nicolas, Copits, Bryan A., Wilson-Poe, Adrianne R., Hipólito, Lucia, Markovic, Tamara, Yoon, Hye Jean, Liu, Shiwei, Walicki, Marie C., Bhatti, Dionnet L., Sirohi, Sunil, Klaas, Amanda, Walker, Brendan M., Neve, Rachael, Cahill, Catherine M., Shoghi, Kooresh I., Gereau, Robert W., McCall, Jordan G., Al-Hasani, Ream, Bruchas, Michael R., Morón, Jose A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509001/
https://ncbi.nlm.nih.gov/pubmed/30878290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.02.029
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