Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models

Cerebral blood flow (CBF) reductions in Alzheimer’s disease (AD) patients and related mouse models have been recognized for decades, but the underlying mechanisms and resulting consequences on AD pathogenesis remain poorly understood. In APP/PS1 and 5xFAD mice we found that an increased number of co...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Neurosci
Main Authors: Cruz Hernández, Jean C., Bracko, Oliver, Kersbergen, Calvin J., Muse, Victorine, Haft-Javaherian, Mohammad, Berg, Maxime, Park, Laibaik, Vinarcsik, Lindsay K., Ivasyk, Iryna, Rivera, Daniel A., Kang, Yiming, Cortes-Canteli, Marta, Peyrounette, Myriam, Doyeux, Vincent, Smith, Amy, Zhou, Joan, Otte, Gabriel, Beverly, Jeffrey D., Davenport, Elizabeth, Davit, Yohan, Lin, Charles P., Strickland, Sidney, Iadecola, Costantino, Lorthois, Sylvie, Nishimura, Nozomi, Schaffer, Chris B.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2019
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6508667/
https://ncbi.nlm.nih.gov/pubmed/30742116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0329-4
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