Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens

Infectious diseases due to multidrug-resistant pathogens, particularly carbapenem-resistant Enterobacteriaceae (CREs), present a major and growing threat to human health and society, providing an urgent need for the development of improved potent antibiotics for their treatment. We describe the desi...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Matsushita, Takahiko, Sati, Girish C., Kondasinghe, Nuwan, Pirrone, Michael G., Kato, Takayuki, Waduge, Prabuddha, Kumar, Harshitha Santhosh, Sanchon, Adrian Cortes, Dobosz-Bartoszek, Malgorzata, Shcherbakov, Dimitri, Juhas, Mario, Hobbie, Sven N., Schrepfer, Thomas, Chow, Christine S., Polikanov, Yury S., Schacht, Jochen, Vasella, Andrea, Böttger, Erik C., Crich, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6508583/
https://ncbi.nlm.nih.gov/pubmed/30793894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b01693
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