A100 PANCREASTATIN WORSENS INTESTINAL INFLAMMATION BY INDUCING CLASSICALLY ACTIVATED MACROPHAGES (M1) THROUGH SUPPRESSION OF STAT3

BACKGROUND: Chromogranin-A (CHGA) levels are increased in inflammatory bowel disease (IBD) and murine models of colitis. CHGA is cleaved in several peptides including the immunoregulatory pancreastatin (PST: CHGA(273-301)), which encodes by CHGA exon-VII. Classically activated macrophages (M1) and s...

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Publicat a:J Can Assoc Gastroenterol
Autors principals: Eissa, N, Kermarrec, L, Hendy, G, Bernstein, C N, Ghia, J
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6508373/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwy009.100
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