Low IGF-I Bioavailability Impairs Growth and Glucose Metabolism in a Mouse Model of Human PAPPA2 p.Ala1033Val Mutation

Bioactive free IGF-I is critically important for growth. The bioavailability of IGF-I is modulated by the IGF-binding proteins (IGFBPs) and their proteases, such as pregnancy-associated plasma protein-A2 (PAPP-A2). We have created a mouse model with a specific mutation in PAPPA2 identified in a huma...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Fujimoto, Masanobu, Andrew, Melissa, Liao, Lihong, Zhang, Dongsheng, Yildirim, Gozde, Sluss, Patrick, Kalra, Bhanu, Kumar, Ajay, Yakar, Shoshana, Hwa, Vivian, Dauber, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6507901/
https://ncbi.nlm.nih.gov/pubmed/30977789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2018-00755
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