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Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin

The therapeutic promise of small-RNA therapeutics is limited, not only by the lack of delivery vehicles, but also by the inability of the small RNAs to reach intracellular compartments where they can be biologically active. We previously reported successful delivery of functionally active miRNAs via...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Orellana, Esteban A., Abdelaal, Ahmed M., Rangasamy, Loganathan, Tenneti, Srinivasarao, Myoung, Sunghyun, Low, Philip S., Kasinski, Andrea L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506612/
https://ncbi.nlm.nih.gov/pubmed/31071527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.04.003
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