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New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K(+)/H(+) Exchange

Although peptides, antibodies/antibody fragments, siRNAs, antisense DNAs, enzymes, and aptamers are all under development as possible therapeutic agents, the breadth of their applications has been severely compromised by their inability to reach intracellular targets. Thus, while macromolecules can...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Rangasamy, Loganathan, Chelvam, Venkatesh, Kanduluru, Ananda Kumar, Srinivasarao, Madduri, Bandara, N. Achini, You, Fei, Orellana, Esteban A., Kasinski, Andrea L., Low, Philip S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926190/
https://ncbi.nlm.nih.gov/pubmed/29446616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00714
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