Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program associated with development and tumor metastasis, is fueled by upregulation of ribosome biogenesis during G1/S arrest....

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Prakash, Varsha, Carson, Brittany B., Feenstra, Jennifer M., Dass, Randall A., Sekyrova, Petra, Hoshino, Ayuko, Petersen, Julian, Guo, Yuan, Parks, Matthew M., Kurylo, Chad M., Batchelder, Jake E., Haller, Kristian, Hashimoto, Ayako, Rundqivst, Helene, Condeelis, John S., Allis, C. David, Drygin, Denis, Nieto, M. Angela, Andäng, Michael, Percipalle, Piergiorgio, Bergh, Jonas, Adameyko, Igor, Farrants, Ann-Kristin Östlund, Hartman, Johan, Lyden, David, Pietras, Kristian, Blanchard, Scott C., Vincent, C. Theresa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506521/
https://ncbi.nlm.nih.gov/pubmed/31068593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10100-8
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