Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program associated with development and tumor metastasis, is fueled by upregulation of ribosome biogenesis during G1/S arrest....

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Vydáno v:Nat Commun
Hlavní autoři: Prakash, Varsha, Carson, Brittany B., Feenstra, Jennifer M., Dass, Randall A., Sekyrova, Petra, Hoshino, Ayuko, Petersen, Julian, Guo, Yuan, Parks, Matthew M., Kurylo, Chad M., Batchelder, Jake E., Haller, Kristian, Hashimoto, Ayako, Rundqivst, Helene, Condeelis, John S., Allis, C. David, Drygin, Denis, Nieto, M. Angela, Andäng, Michael, Percipalle, Piergiorgio, Bergh, Jonas, Adameyko, Igor, Farrants, Ann-Kristin Östlund, Hartman, Johan, Lyden, David, Pietras, Kristian, Blanchard, Scott C., Vincent, C. Theresa
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506521/
https://ncbi.nlm.nih.gov/pubmed/31068593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10100-8
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