USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability

Resistance to platinum-based chemotherapy is a common event in patients with cancer, generally associated with tumor dissemination and metastasis. Whether platinum treatment per se activates molecular pathways linked to tumor spreading is not known. Here, we report that the ubiquitin-specific protea...

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Pubblicato in:Sci Adv
Autori principali: Sonego, Maura, Pellarin, Ilenia, Costa, Alice, Vinciguerra, Gian Luca Rampioni, Coan, Michela, Kraut, Alexandra, D’Andrea, Sara, Dall’Acqua, Alessandra, Castillo-Tong, Dan Cacsire, Califano, Daniela, Losito, Simona, Spizzo, Riccardo, Couté, Yohann, Vecchione, Andrea, Belletti, Barbara, Schiappacassi, Monica, Baldassarre, Gustavo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506239/
https://ncbi.nlm.nih.gov/pubmed/31086816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav3235
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