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Acetylation blocks DNA damage-induced chromatin ADP-ribosylation
Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6505472/ https://ncbi.nlm.nih.gov/pubmed/30013063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0097-1 |
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