Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress

Background: Random skin flap is frequently used in plastic and reconstructive surgery, but its distal part often occurs ischemia and necrosis. Pravastatin (Prava) with bioactivities of pro-angiogenesis, anti-apoptosis and anti-oxidative stress, may be beneficial for flap survival. Materials and meth...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Lin, Jinti, Jia, Chang, Wang, Yongli, Jiang, Shanghong, Jia, Zhenyu, Chen, Nan, Sheng, Shimin, Li, Shihen, Jiang, Liangfu, Xu, Huazi, Zhou, Kailiang, Chen, Yijie
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505465/
https://ncbi.nlm.nih.gov/pubmed/31118580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S195479
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