Valproic acid enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress and apoptosis

BACKGROUND: Random skin flaps are commonly applied during plastic surgery, but distal flap necrosis limits their clinical applications. Valproic acid (VPA), a histone deacetylase inhibitor and a traditional antiepileptic agent, may promote flap survival. MATERIALS AND METHODS: Sprague–Dawley rats we...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Wu, Hongqiang, Ding, Jian, Wang, Lei, Lin, Jinti, Li, Shihen, Xiang, Guangheng, Jiang, Liangfu, Xu, Huazi, Gao, Weiyang, Zhou, Kailiang
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248271/
https://ncbi.nlm.nih.gov/pubmed/30510403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S186222
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