A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B)

Mutations of EXOSC3 have been linked to the rare neurological disorder known as Pontocerebellar Hypoplasia type 1B (PCH1B). EXOSC3 is one of three putative RNA-binding structural cap proteins that guide RNA into the RNA exosome, the cellular machinery that degrades RNA. Using RNAcompete, we identifi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Chem Biol
Prif Awduron: François-Moutal, Liberty, Jahanbakhsh, Shahriyar, Nelson, Andrew D. L., Ray, Debashish, Scott, David D., Hennefarth, Matthew R., Moutal, Aubin, Perez-Miller, Samantha, Ambrose, Andrew J., Al-Shamari, Ahmed, Coursodon, Philippe, Meechoovet, Bessie, Reiman, Rebecca, Lyons, Eric, Beilstein, Mark, Chapman, Eli, Morris, Quaid D., Van Keuren-Jensen, Kendall, Hughes, Timothy R., Khanna, Rajesh, Koehler, Carla, Jen, Joanna, Gokhale, Vijay, Khanna, May
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504997/
https://ncbi.nlm.nih.gov/pubmed/30141626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00745
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