A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B)

Mutations of EXOSC3 have been linked to the rare neurological disorder known as Pontocerebellar Hypoplasia type 1B (PCH1B). EXOSC3 is one of three putative RNA-binding structural cap proteins that guide RNA into the RNA exosome, the cellular machinery that degrades RNA. Using RNAcompete, we identifi...

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Publicat a:ACS Chem Biol
Autors principals: François-Moutal, Liberty, Jahanbakhsh, Shahriyar, Nelson, Andrew D. L., Ray, Debashish, Scott, David D., Hennefarth, Matthew R., Moutal, Aubin, Perez-Miller, Samantha, Ambrose, Andrew J., Al-Shamari, Ahmed, Coursodon, Philippe, Meechoovet, Bessie, Reiman, Rebecca, Lyons, Eric, Beilstein, Mark, Chapman, Eli, Morris, Quaid D., Van Keuren-Jensen, Kendall, Hughes, Timothy R., Khanna, Rajesh, Koehler, Carla, Jen, Joanna, Gokhale, Vijay, Khanna, May
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504997/
https://ncbi.nlm.nih.gov/pubmed/30141626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00745
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