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Off the street phasing (OTSP): no hassle haplotype phasing for molecular PGD applications

PURPOSE: Pre-implantation genetic diagnosis (PGD) for molecular disorders requires the construction of parental haplotypes. Classically, haplotype resolution (“phasing”) is obtained by genotyping multiple polymorphic markers in both parents and at least one additional relative. However, this process...

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Detalhes bibliográficos
Publicado no:J Assist Reprod Genet
Main Authors: Zeevi, David A., Zahdeh, Fouad, Kling, Yehuda, Carmi, Shai, Altarescu, Gheona
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504987/
https://ncbi.nlm.nih.gov/pubmed/30617673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-018-1392-1
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