DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system with a modest concordance rate in monozygotic twins, which strongly argues for involvement of epigenetic factors. We observe highly similar peripheral blood mononuclear cell-based methylomes in 45 MS-disc...

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Pubblicato in:Nat Commun
Autori principali: Souren, Nicole Y., Gerdes, Lisa A., Lutsik, Pavlo, Gasparoni, Gilles, Beltrán, Eduardo, Salhab, Abdulrahman, Kümpfel, Tania, Weichenhan, Dieter, Plass, Christoph, Hohlfeld, Reinhard, Walter, Jörn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504952/
https://ncbi.nlm.nih.gov/pubmed/31064978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09984-3
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