The Angiotensin Receptor Blocker Losartan Suppresses Growth of Pulmonary Metastases via AT1R-Independent Inhibition of CCR2 Signaling and Monocyte Recruitment

Inflammatory monocytes (IMs) have been shown to play key roles in cancer metastasis through promotion of tumor cell extravasation, growth, and angiogenesis. Monocyte recruitment to metastases is mediated primarily via the CCL2-CCR2 chemotactic axis. Thus, disruption of this axis represents an attrac...

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Pubblicato in:J Immunol
Autori principali: Regan, Daniel P., Coy, Jonathan W., Chahal, Kirti Kandhwal, Chow, Lyndah, Kurihara, Jade N., Guth, Amanda M., Kufareva, Irina, Dow, Steven W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504574/
https://ncbi.nlm.nih.gov/pubmed/30971441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800619
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