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The Angiotensin Receptor Blocker Losartan Suppresses Growth of Pulmonary Metastases via AT1R-Independent Inhibition of CCR2 Signaling and Monocyte Recruitment

Inflammatory monocytes (IMs) have been shown to play key roles in cancer metastasis through promotion of tumor cell extravasation, growth, and angiogenesis. Monocyte recruitment to metastases is mediated primarily via the CCL2-CCR2 chemotactic axis. Thus, disruption of this axis represents an attrac...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Regan, Daniel P., Coy, Jonathan W., Chahal, Kirti Kandhwal, Chow, Lyndah, Kurihara, Jade N., Guth, Amanda M., Kufareva, Irina, Dow, Steven W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504574/
https://ncbi.nlm.nih.gov/pubmed/30971441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800619
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