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Developmental increase in β-MHC enhances sarcomere length–dependent activation in the myocardium
Shifts in myosin heavy chain (MHC) isoforms in cardiac myocytes have been shown to alter cardiac muscle function not only in healthy developing hearts but also in diseased hearts. In guinea pig hearts, there is a large age-dependent shift in MHC isoforms from 80% α-MHC/20% β-MHC at 3 wk to 14% α-MHC...
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| Publicado en: | J Gen Physiol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6504293/ https://ncbi.nlm.nih.gov/pubmed/30602626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812183 |
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