Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior

It remains unclear to what extent neurodevelopmental disorder (NDD) risk genes retain functions into adulthood and how they may influence disease phenotypes. SYNGAP1 haploinsufficiency causes a severe NDD defined by autistic traits, cognitive impairment, and epilepsy. To determine if this gene retai...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Creson, Thomas K, Rojas, Camilo, Hwaun, Ernie, Vaissiere, Thomas, Kilinc, Murat, Jimenez-Gomez, Andres, Holder, Jimmy Lloyd, Tang, Jianrong, Colgin, Laura L, Miller, Courtney A, Rumbaugh, Gavin
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504227/
https://ncbi.nlm.nih.gov/pubmed/31025938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46752
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