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Single-Molecule Force Measurement Guides the Design of Multivalent Ligand with Picomolar Affinity
Interaction of multiple entities and receptors, or multivalency is widely applied to achieve high affinity ligands for diagnostic and therapeutic purpose. However, lack of knowledge on receptor distribution in living subjects remains a challenge for rational structure design. Here, we developed a fo...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6503962/ https://ncbi.nlm.nih.gov/pubmed/30697890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201814347 |
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