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Single-Molecule Force Measurement Guides the Design of Multivalent Ligand with Picomolar Affinity
Interaction of multiple entities and receptors, or multivalency is widely applied to achieve high affinity ligands for diagnostic and therapeutic purpose. However, lack of knowledge on receptor distribution in living subjects remains a challenge for rational structure design. Here, we developed a fo...
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| Publicat a: | Angew Chem Int Ed Engl |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6503962/ https://ncbi.nlm.nih.gov/pubmed/30697890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201814347 |
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