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Conformationally Regulated Peptide Bond Cleavage in Bradykinin
Ion mobility and mass spectrometry techniques are used to investigate the stabilities of different conformations of bradykinin (BK, Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)). At elevated solution temperatures, we observe a slow protonation reaction, i.e., [BK+2H](2+)+H(+) → [BK...
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| Publié dans: | J Am Chem Soc |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6503673/ https://ncbi.nlm.nih.gov/pubmed/30028131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04751 |
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