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Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors
The CRISPR-Cas9 system is used for genome editing in mammalian cells by introducing double-strand breaks (DSBs) which are predominantly repaired via non-homologous end joining (NHEJ) or to lesser extent by homology-directed repair (HDR). To enhance HDR for improving the introduction of precise genet...
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| Опубликовано в: : | Front Genet |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6503098/ https://ncbi.nlm.nih.gov/pubmed/31114605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00365 |
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