Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors

The CRISPR-Cas9 system is used for genome editing in mammalian cells by introducing double-strand breaks (DSBs) which are predominantly repaired via non-homologous end joining (NHEJ) or to lesser extent by homology-directed repair (HDR). To enhance HDR for improving the introduction of precise genet...

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Publicado en:Front Genet
Autores principales: Tran, Ngoc-Tung, Bashir, Sanum, Li, Xun, Rossius, Jana, Chu, Van Trung, Rajewsky, Klaus, Kühn, Ralf
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503098/
https://ncbi.nlm.nih.gov/pubmed/31114605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00365
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