Staphylococcal and Streptococcal Superantigens Trigger B7/CD28 Costimulatory Receptor Engagement to Hyperinduce Inflammatory Cytokines

Staphylococcal and streptococcal superantigens are virulence factors that cause toxic shock by hyperinducing inflammatory cytokines. Effective T-cell activation requires interaction between the principal costimulatory receptor CD28 and its two coligands, B7-1 (CD80) and B7-2 (CD86). To elicit an inf...

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Publicado en:Front Immunol
Autores principales: Popugailo, Andrey, Rotfogel, Ziv, Supper, Emmanuelle, Hillman, Dalia, Kaempfer, Raymond
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503043/
https://ncbi.nlm.nih.gov/pubmed/31114583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00942
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