Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock

Bacterial superantigens, a diverse family of toxins, induce an inflammatory cytokine storm that can lead to lethal shock. CD28 is a homodimer expressed on T cells that functions as the principal costimulatory ligand in the immune response through an interaction with its B7 coligands, yet we show her...

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Detalhes bibliográficos
Main Authors: Arad, Gila, Levy, Revital, Nasie, Iris, Hillman, Dalia, Rotfogel, Ziv, Barash, Uri, Supper, Emmanuelle, Shpilka, Tomer, Minis, Adi, Kaempfer, Raymond
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172200/
https://ncbi.nlm.nih.gov/pubmed/21931534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001149
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