Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota

Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it was effective against cerebral ischemic/reperfusion (I/R) injury. The pharmacologically active component and targeting site of crocin remain elusive. In this study, the cerebral-protective e...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Zhang, Yue, Geng, Jianliang, Hong, Yu, Jiao, Li, Li, Shuning, Sun, Runbin, Xie, Yuan, Yan, Caixia, Aa, Jiye, Wang, Guangji
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502977/
https://ncbi.nlm.nih.gov/pubmed/31114499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00440
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