Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota

Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it was effective against cerebral ischemic/reperfusion (I/R) injury. The pharmacologically active component and targeting site of crocin remain elusive. In this study, the cerebral-protective e...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Zhang, Yue, Geng, Jianliang, Hong, Yu, Jiao, Li, Li, Shuning, Sun, Runbin, Xie, Yuan, Yan, Caixia, Aa, Jiye, Wang, Guangji
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502977/
https://ncbi.nlm.nih.gov/pubmed/31114499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00440
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