Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota

Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it was effective against cerebral ischemic/reperfusion (I/R) injury. The pharmacologically active component and targeting site of crocin remain elusive. In this study, the cerebral-protective e...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Pharmacol
Prif Awduron: Zhang, Yue, Geng, Jianliang, Hong, Yu, Jiao, Li, Li, Shuning, Sun, Runbin, Xie, Yuan, Yan, Caixia, Aa, Jiye, Wang, Guangji
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019
Pynciau:
Pharmacology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502977/
https://ncbi.nlm.nih.gov/pubmed/31114499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00440
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