Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver

Familial hypercholesterolemia (FH) is an inherited disease of lipoprotein metabolism caused by a defect in the LDL receptor (LDLR) leading to severe hypercholesterolemia, and associated with an increased risk of coronary heart disease and myocardial infarction. We have developed a gene therapy proto...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Hytönen, Elisa, Laurema, Anniina, Kankkonen, Hanna, Miyanohara, Atsushi, Kärjä, Vesa, Hujo, Mika, Laham-Karam, Nihay, Ylä-Herttuala, Seppo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502883/
https://ncbi.nlm.nih.gov/pubmed/31061510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43459-1
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