Sleeping Beauty Transposon Vectors in Liver-directed Gene Delivery of LDLR and VLDLR for Gene Therapy of Familial Hypercholesterolemia

Plasmid-based Sleeping Beauty (SB) transposon vectors were developed and used to deliver genes for low-density lipoprotein and very-low-density lipoprotein receptors (LDLR and VLDLR, respectively) or lacZ reporter into liver of an LDLR-deficient mouse model of familial hypercholesterolemia (FH). SB...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Turunen, Tytteli A K, Kurkipuro, Jere, Heikura, Tommi, Vuorio, Taina, Hytönen, Elisa, Izsvák, Zsuzsanna, Ylä-Herttuala, Seppo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786919/
https://ncbi.nlm.nih.gov/pubmed/26670130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.221
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