Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver

Familial hypercholesterolemia (FH) is an inherited disease of lipoprotein metabolism caused by a defect in the LDL receptor (LDLR) leading to severe hypercholesterolemia, and associated with an increased risk of coronary heart disease and myocardial infarction. We have developed a gene therapy proto...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hytönen, Elisa, Laurema, Anniina, Kankkonen, Hanna, Miyanohara, Atsushi, Kärjä, Vesa, Hujo, Mika, Laham-Karam, Nihay, Ylä-Herttuala, Seppo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502883/
https://ncbi.nlm.nih.gov/pubmed/31061510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43459-1
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