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HIV gp120 upregulates tonic inhibition through α5-containing GABA(A)Rs

HIV-Associated Neurocognitive disorder (HAND) affects nearly half of infected patients. The HIV envelope protein gp120 is shed by infected cells and is a potent neurotoxin in vitro that reproduces many aspects of HAND when expressed in vivo. Here, we show that HIV gp120 increases the amplitude of a...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Green, Matthew V., Thayer, Stanley A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501829/
https://ncbi.nlm.nih.gov/pubmed/30797029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.02.024
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