Flap-site fragment restores back wild-type behaviour in resistant form of HIV protease

HIV-1 protease (HIV-PR) performs a vital step in the virus life cycle which makes it an excellent target for drug therapy. However, due to the error-prone of HIV reverse transcriptase, mutations in HIV-PR often occur, inducing drug-resistance to inhibitors. Some HIV-PR mutations can make the flaps o...

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Bibliographic Details
Published in:Mol Inform
Main Authors: Luchi, Adriano, Angelina, Emilio, Bogado, Lucrecia, Forli, Stefano, Olson, Arthur, Peruchena, Nélida
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501176/
https://ncbi.nlm.nih.gov/pubmed/30051611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/minf.201800053
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