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Structural insight into TRPV5 channel function and modulation

TRPV5 (transient receptor potential vanilloid 5) is a unique calcium-selective TRP channel essential for calcium homeostasis. Unlike other TRPV channels, TRPV5 and its close homolog, TRPV6, do not exhibit thermosensitivity or ligand-dependent activation but are constitutively open at physiological m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dang, Shangyu, van Goor, Mark K., Asarnow, Daniel, Wang, YongQiang, Julius, David, Cheng, Yifan, van der Wijst, Jenny
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500171/
https://ncbi.nlm.nih.gov/pubmed/30975749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820323116
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