α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by the deposition of β-sheet–rich, insoluble amyloid β-peptide (Aβ) plaques; however, plaque burden is not correlated with cognitive impairment in AD patients; instead, it is correlated with the presence of toxic soluble oligomers. Here, we show, by a variet...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Shea, Dylan, Hsu, Cheng-Chieh, Bi, Timothy M., Paranjapye, Natasha, Childers, Matthew Carter, Cochran, Joshua, Tomberlin, Colson P., Wang, Libo, Paris, Daniel, Zonderman, Jeffrey, Varani, Gabriele, Link, Christopher D., Mullan, Mike, Daggett, Valerie
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500163/
https://ncbi.nlm.nih.gov/pubmed/31004062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820585116
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