Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution

The mammalian CNS is capable of tolerating chronic hypoxia, but cell type-specific responses to this stress have not been systematically characterized. In the Norrin KO (Ndp(KO)) mouse, a model of familial exudative vitreoretinopathy (FEVR), developmental hypovascularization of the retina produces c...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Heng, Jacob S., Rattner, Amir, Stein-O’Brien, Genevieve L., Winer, Briana L., Jones, Bryan W., Vernon, Hilary J., Goff, Loyal A., Nathans, Jeremy
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500147/
https://ncbi.nlm.nih.gov/pubmed/30988181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821122116
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