Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing

Autoimmune uveoretinitis is a significant cause of visual loss, and mouse models offer unique opportunities to study its disease mechanisms. Aire(−/−) mice fail to express self-antigens in the thymus, exhibit reduced central tolerance, and develop a spontaneous, chronic, and progressive uveoretiniti...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Heng, Jacob S., Hackett, Sean F., Stein-O’Brien, Genevieve L., Winer, Briana L., Williams, John, Goff, Loyal A., Nathans, Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936593/
https://ncbi.nlm.nih.gov/pubmed/31843893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915571116
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